Tirzepatide (LY3298176) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1
Type 2 Diabetes: Tirzepatide is used in conjunction with diet and exercise to help improve blood sugar control in adults with type 2 diabetes.Chronic Weight Management: It's also used to help with weight loss and weight maintenance in adults with obesity or those who are overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, high cholesterol, or obstructive sleep apnea.
Tirzepatide's efficacy for chronic weight management (weight reduction and maintenance) in combination with a reduced-calorie diet and increased physical activity was established placebo-controlled trials of adults with obesity or overweight with at least one weight-related condition.
These studies measured weight reduction after 72 weeks in 2,519 participants who received either 5 mg, 10 mg, or 15 mg of tirzepatide once weekly and 958 participants who received weekly placebo injections. In both trials, after 72 weeks of treatment, participants who received tirzepatide at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of participants who received tirzepatide achieved at least 5% weight reduction compared to placebo
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